Efficacy and safety of tenofovir disoproxyl fumarate monotherapy | Clinical Gastroenterology and Hepatology - MD Linx

Advertisement

In patients with multidrug-resistant chronic hepatitis B virus (HBV) infections, researchers examined the effectiveness of tenofovir disoproxyl fumarate (TDF) monotherapy and TDF-based combination therapy for viral suppression as rescue therapy by conducting a multicenter, prospective, real-world cohort study. From eight tertiary hospitals in Korea, patients with chronic HBV infection resistant to antivirals were recruited. In total, 174 patients were treated with TDF monotherapy and 249 were treated with combination therapy based on TDF. In the majority of patients with MDR who received TDF monotherapy or TDF-based combination therapy during long-term follow-up, a virologic response (defined as a serum HBV DNA level of <20 IU/mL) was achieved, and the rates were not significantly different. In patients with MDR, long-term use of TDF monotherapy demonstrated non-inferior antiviral efficacy vs that of TDF-based combination therapy.

Read the full article on Clinical Gastroenterology and Hepatology



http://bit.ly/2wwpD25

Comments

Popular posts from this blog

Strays welcome - Ways you can reach out to help lonely and neglected animals

Best Pet Insurance Companies & Plans 2024 | U.S. News

Binghamton Plaza Shop Owners Concerned About Eminent Domain ...