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BullFrog AI And Eleison Pharmaceuticals Enter Agreement To Collaborate To Optimize Pivotal Phase 3 Trial
GAITHERSBURG, Md., Feb. 27, 2025 (GLOBE NEWSWIRE) -- BullFrog AI Holdings, Inc. (NASDAQ: BFRG; BFRGW) ("BullFrog AI" or the "Company"), a technology-enabled drug development company using artificial intelligence (AI) and machine learning to enable the successful development of pharmaceuticals and biologics, today announced its entry into a collaboration agreement with Eleison Pharmaceuticals Inc. ("Eleison"), a Phase 3 oncology company focused on novel chemotherapeutic treatments for rare cancers. Under the terms of the agreement, BullFrog AI will provide access to its BullFrog Data Networks™ AI solution to enhance clinical trial efficiency and patient insights. Financial terms of the collaboration were not disclosed.
"The integration of artificial intelligence in clinical trials represents a transformative shift in how pharmaceutical companies can de-risk drug development and optimize patient outcomes," said Vin Singh, CEO of BullFrog AI. "We are thrilled to partner with Eleison to apply our bfLEAP® AI technology, which has the potential to refine patient selection, improve trial efficiency, and ultimately accelerate the path to market for life-saving therapies."
Through this collaboration, BullFrog AI will apply its proprietary BullFrog Data Networks™ solution,
Glufosfamide is a third-generation alkylating agent designed for greater specificity and tumor uptake, with reduced systemic toxicities and side effects. It is currently being evaluated by Eleison in a pivotal Phase 3 international randomized clinical trial, for the second-line treatment of patients with pancreatic cancer. Although pancreatic cancer is among the rarer cancer types, it is the third leading cause of death by cancer in the United States. More than 67,000 Americans and 510,000 people worldwide are diagnosed with pancreatic cancer annually. Few therapeutic options exist to treat the disease and five-year survival rates are typically less than 5%. Eleison expects to complete this ongoing Phase 3 trial in 2027.
"Our collaboration with BullFrog AI underscores our commitment to innovation in drug development," said Edwin Thomas, CEO of Eleison. "By leveraging AI-powered analytics, we aim to generate deeper insights into patient responses and safety trends, which will not only benefit our glufosfamide program but also inform the strategic direction of our broader oncology pipeline."
About BullFrog AI
BullFrog AI leverages Artificial Intelligence and machine learning to advance drug discovery and development. Through collaborations with leading research institutions, BullFrog AI uses causal AI in combination with its proprietary bfLEAP™ platform to analyze complex biological data, aiming to streamline therapeutics development and reduce failure rates in clinical trials.
For more information, visit BullFrog AI at: https://bullfrogai.Com
About Eleison Pharmaceuticals
Eleison's mission is to acquire and develop drug candidates with existing and significant safety and efficacy data; and ultimately to obtain regulatory approval and commercialize new therapeutics for patients with life-threatening cancers. In addition to its glufosfamide program, the Company has two other programs in late-stage clinical development; ILC in development for small cell lung cancer and pediatric osteosarcoma, and DBD for brain cancers. The Company has entered into development and marketing partnerships with leading pharmaceutical companies in China, S. Korea, and Israel. Eleison was founded in 2009 and is headquartered in Princeton, NJ. Additional information about Eleison can be found at our website www.Eleison-pharma.Com.
Safe Harbor Statement
This press release contains forward-looking statements. We base these forward-looking statements on our expectations and projections about future events, which we derive from the information currently available to us. Such forward-looking statements relate to future events or our future performance, including: our financial performance and projections; our growth in revenue and earnings; and our business prospects and opportunities. You can identify forward-looking statements by those that are not historical in nature, particularly those that use terminology such as "may," "should," "could," "will," "expects," "anticipates," "contemplates," "estimates," "believes," "plans," "projected," "predicts," "potential," or "hopes" or the negative of these or similar terms. In evaluating these forward-looking statements, you should consider various factors, including: our ability to change the direction of the Company; our ability to keep pace with new technology and changing market needs; and the competitive environment of our business. These and other factors may cause our actual results to differ materially from any forward-looking statement. Forward-looking statements are only predictions. The forward-looking events discussed in this press release and other statements made from time to time by us or our representatives, may not occur, and actual events and results may differ materially and are subject to risks, uncertainties, and assumptions about us. We are not obligated to publicly update or revise any forward-looking statement, whether as a result of uncertainties and assumptions, the forward-looking events discussed in this press release and other statements made from time to time by us or our representatives might not occur.
Contact:
Dave GentryRedChip Companies, Inc.1-407-644-4256BFRG@redchip.Com
This Tadpole Larger Than A Human Hand Could Never Become A Frog. Here's What We Know
Claim:A photograph shared online genuinely shows an exceptionally large tadpole roughly the size of a soda can or human hand.
A photograph of a giant, green-and-yellow tadpole longer than a human hand turned up in an X post on Feb. 12, 2025. At the time of this reporting, the post had received more than 296,000 views.
People have been sharing the photograph on social media platforms, including Reddit and Facebook, for years, as well as by online publications like the New York Post and Live Science.
Herpetologist Earyn McGee, a self-described "lizard lassoer," originally shared the photo on X on June 13, 2018. McGee described the tadpole as "not the norm" and an "outlier with some sort of hormonal imbalance."
McGee served as a PhD candidate at the University of Arizona in the School of Natural Resources and the Environment, according to an online profile published by the American Association for the Advancement of Science.
In a subsequent post, McGee compared the size of the tadpole to that of a banana.
Snopes contacted McGee for further information about the tadpole's condition and will update this article if we learn more.
McGee shared a video and update of the aptly named "Goliath" tadpole on May 26, 2020, writing that the tadpole died in 2019 for unknown reasons. Researchers at the time intended to continue studying the tadpole and planned to publish their findings in the following years, wrote McGee.
The science and technology publication American Scientist wrote about the "record-breaking, 10-inch-long whopper of a bullfrog tadpole" in 2018, noting that it was discovered by a "a crew of ecologists in a pond in the Chiricahua Mountains of Arizona."
The crew was working at Arizona's Southwestern Research Station, a field station under the direction of the Science Department of the American Museum of Natural History.
Alina Downer, an intern at the time, reportedly found the bullfrog tadpole while her crew was draining a manmade pond during a habitat restoration project. The "gigantic pollywog" measured 10.1 inches long, beating the previous species record by 2.5 inches, according to American Scientist, which described the amphibian as being:
… larger in circumference than a can of soda. Its head is around the size of a big adult bullfrog, but is round and blunt-faced like a tadpole, with fishy tadpole lips rather than a frog mouth.
How old the tadpole was or what caused its abnormal growth was unknown, though an imbalance of hormones is suspected of causing its comparatively colossal size.
Snopes contacted the Southwest Research Station for further information about whether researchers had characterized the tadpole and described its condition. We will update this article if a response is received.
The American Museum of Natural History writes that American bullfrog tadpoles, scientific name Rana catesbeiana, more typically reach 4 to 6 inches in length and can take up to two years to metamorphose into a frog.
Most frogs and other amphibians hatch as fish-like larvae called tadpoles, or "pollywogs." Tadpoles exist to eat and grow. They eventually transform into froglets, a process called metamorphosis. These soft globs of flesh provide tasty morsels for snakes, fish, birds, and even other frogs. The tadpole stage can last for days or years, depending on the species and the weather.
Arizona Game and Fish (AGF) considers the bullfrog an invasive aquatic animal species introduced to the western U.S. In the early 1900s for "sport, food, and inadvertently during fish stockings." AGF writes:
Bullfrogs reproduce prolifically, laying up to 20,000 eggs in a single clutch and are capable of spreading without human intervention. Bullfrogs compete with and often prey upon many native aquatic species including fish, turtles, snakes, and a variety of invertebrates. Of particular concern are the detrimental effects that bullfrogs have on the federally-listed Chiricahua leopard frog and Mexican garter snake. In addition to preying on or competing with these species, bullfrogs may harbor deadly diseases such as chytridiomycosis that can infect native amphibians (Garner et al. 2007). Efforts to remove bullfrogs from habitats where Chiricahua leopard frogs occur or will be introduced is an AZGFD management strategy that has been effective in several large landscapes in southeastern Arizona.
The Natural Resources Defense Council notes that adult bullfrogs can reach up to 8 inches in length – twice the size of the threatened Chiricahua leopard frog, the latter of which can wind up as dinner for bullfrogs.
Snopes has looked into other online claims involving frogs, including whether one Alaskan species can survive for weeks after freezing in winter and another said to have eyes inside their mouths.
Sources8. Invasive and Problematic SpeciesArizona Wildlife Conservation Strategy. Https://awcs.Azgfd.Com/conservation-challenges/invasive-and-problematic-species. Accessed 23 Feb. 2025.
"About." Dr. Earyn McGee, https://earynmcgee.Com/about. Accessed 23 Feb. 2025.
Evon, Dan. "Are These Frogs with Eyes Inside Their Mouths Real?" Snopes, 30 Apr. 2021, https://www.Snopes.Com//fact-check/frog-eyes-inside-mouth/.
Lapin, Tamar. Researchers Catch Biggest Tadpole on Record. 14 June 2018, https://nypost.Com/2018/06/14/researchers-catch-gigantic-tadpole-in-arizona/.
Mikkelson, David. "FACT CHECK: Can These Frogs Survive After Freezing in Winter?" Snopes, 5 Feb. 2015, https://www.Snopes.Com//fact-check/frozen-frogs/.
published, Mindy Weisberger. "Meet Goliath, a Massive Tadpole as Long as Your Face." Livescience.Com, 27 May 2020, https://www.Livescience.Com/63238-goliath-giant-tadpole.Html.
Q&A: Lizard-Loving PhD Student Earyn McGeeResearch, Innovation, and Impact. 10 July 2018, https://research.Arizona.Edu/stories/lizard-loving-phd-student-earyn-mcgee.
The Bullfrog Is the "Great White Shark" of Arizona's Wetlands. 31 Aug. 2018, https://www.Nrdc.Org/stories/bullfrog-great-white-shark-arizonas-wetlands.
"The Giant Tadpole That Never Got Its Legs." American Scientist, 30 July 2018, https://www.Americanscientist.Org/blog/from-the-staff/the-giant-tadpole-that-never-got-its-legs.
Bullfrog AI Providing AI Solution For Eleison Pharmaceuticals Phase 3 Trials
BullFrog AI (BFRG) announced its entry into a collaboration agreement with Eleison Pharmaceuticals, a Phase 3 oncology company focused on novel chemotherapeutic treatments for rare cancers, under which BullFrog AI will provide access to its BullFrog Data Networks AI solution to enhance clinical trial efficiency and patient insights. Financial terms of the collaboration were not disclosed. Through this collaboration, BullFrog AI will apply its proprietary BullFrog Data Networkssolution, Discover the Best Stocks and Maximize Your Portfolio:
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